Purdue University-Main Campus · BiologyBladder Cancer Immunotherapy Lab
Deborah W Knapp · West Lafayette, Indiana
Research Focus
Dr. Deborah W. Knapp's lab at Purdue University focuses on improving cancer treatment through innovative research on immune cell responses in both dogs and humans with invasive urinary bladder cancer. By studying naturally-occurring bladder cancer in dogs, the lab aims to advance immunotherapy techniques that can enhance outcomes in human patients. This research not only contributes to better therapy options for bladder cancer but also aims to harness the canine model to explore solutions for other types of cancer.
immunotherapybladder cancercanine modelimmune checkpoint inhibitorscomparative oncologycancer immunotherapyRNA sequencingclinical trialspredictive biomarkers
Research Aims
5AIM 01Investigate immune cell responses in dogs with bladder cancer compared to humans.
AIM 02Assess the effectiveness and safety of a canine PD-L1 antibody in treating bladder cancer.
AIM 03Identify predictors of treatment success and failure in canine and human patients.
AIM 04Utilize canine models to enhance human immunotherapy outcomes.
AIM 05Contribute data to canine cancer research networks for broader applications.
Skills the Lab Values
RNA sequencingclinical trial designdata analysisbioinformaticshumans and canine immune cell comparisonanimal model studiesclinical data collectionCITE-seqwhole genome sequencing
Output against the department
Publications223top 28% of dept.289th of 1,033
this lab
most publishedleast published
Citations8.6ktop 44% of dept.459th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.