UTMThe University of Texas MD Anderson Cancer Center · Biochemistry
Lung Cancer Genetics and Prevention Lab
Humam Kadara · Houston, Texas
Research Focus
Dr. Humam Kadara's lab focuses on understanding how specific lung cells evolve into cancerous cells due to tobacco exposure. By studying the genetic and inflammatory changes that occur in lung tissues, the lab aims to uncover new ways to prevent lung adenocarcinoma, especially in smokers. This research is critical for developing early intervention strategies to combat this common type of lung cancer.
lung cancerKRAS mutationstobacco exposuresingle-cell RNA sequencingpremalignant lesions
Research Aims
4AIM 01Characterize the evolution of Krt8+ alveolar cells to premalignant lesions and KRAS-mutant lung adenocarcinoma.
AIM 02Determine the role of p53 signaling in the progression of these cells to cancer.
AIM 03Investigate the effects of pro-inflammatory signaling on the development of alveolar cells into lung cancer.
AIM 04Identify potential therapeutic targets to intercept the progression of lung adenocarcinoma.
Skills the Lab Values
single-cell RNA sequencingmouse modelsdrug screeningcell culturemolecular biology techniques
Output against the department
Publications526top 8% of dept.32nd of 402
this lab
most publishedleast published
Citations11ktop 47% of dept.187th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.