Northwestern University · NeuroscienceKalb Neurodegeneration Lab
Robert G Kalb · Evanston, Illinois
Research Focus
Dr. Robert G Kalb's lab at Northwestern University focuses on understanding the mechanisms behind frontotemporal dementia (FTD), particularly those associated with the C9orf72 gene mutation. The research utilizes model organisms like C. elegans and mammalian neurons to explore how specific toxic proteins generated from the mutated gene cause neurodegeneration. The lab aims to identify protective pathways and potential drug targets to help treat this challenging and prevalent neurodegenerative disease.
C9orf72frontotemporal dementianeurodegenerationDPR toxicityubiquitination
Research Aims
3AIM 01Define the interaction between DPRs and SPOP in neuronal contexts.
AIM 02Elucidate pathways by which SPOP modulates DPR toxicity.
AIM 03Investigate SPOP as a target for therapeutic intervention in FTD.
Skills the Lab Values
C. elegans modelsmammalian cell culturegenetic screeningprotein assaystoxicology assessments
Output against the department
Publications137bottom 48% of dept.348th of 671
this lab
most publishedleast published
Citations12ktop 35% of dept.236th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.