Northwestern University · BiologyVascular Biology and Cancer Lab
M. Luisa Iruela-Arispe · Evanston, Illinois
Research Focus
Dr. M. Luisa Iruela-Arispe's lab at Northwestern University focuses on understanding how genetic mutations and cellular mechanisms contribute to vascular abnormalities and cancer-related complications. The lab investigates specific genetic mutations that create fragile blood vessels responsible for serious conditions like arteriovenous malformations. Additionally, they study the impact of cancer on the body's vascular system, particularly how it can lead to weight loss and cachexia, to identify potential therapeutic interventions.
vascular malformationsRASA1cancer cachexiaendothelial biologyvascular integrity
Research Aims
5AIM 01Identify genetic mutations that collaborate with RASA1 to cause vascular malformations.
AIM 02Develop therapies to restore vascular integrity in patients with RASA1 mutations.
AIM 03Investigate how cancer affects the vascular system and contributes to weight loss.
AIM 04Explore molecular mechanisms of cachexia to find effective treatments.
AIM 05Evaluate the role of endothelial cells in the development of vascular anomalies.
Skills the Lab Values
mouse modelsgenetic screeningcell culturemolecular assaysWestern blotPCRimmunohistochemistrytissue analysisbioinformatics
Output against the department
Publications357top 14% of dept.145th of 1,033
this lab
most publishedleast published
Citations29ktop 12% of dept.124th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.