Stanford University · GeneticsMicrofluidic Immunotherapy Lab
Polly Morrell Fordyce · Stanford, California
Research Focus
Dr. Polly Morrell Fordyce's lab focuses on developing innovative microfluidic technologies to enhance personalized anti-cancer immunotherapies. By studying the interactions between T cell receptors and antigen-presenting molecules, the lab aims to identify which combinations can effectively activate T cells to combat cancer cells. This research seeks to improve the prediction of T cell responses, paving the way for safer and more effective immunotherapies.
microfluidicsanti-cancer therapiesT cell activationneoantigensbiomechanicspersonalized medicineimmunotherapyT cell receptorspeptide vaccines
Research Aims
5AIM 01Develop new microfluidic tools to test T cell and pMHC interactions.
AIM 02Identify which pMHC/TCR combinations form strong catch bonds under physiological forces.
AIM 03Enhance predictions of T cell activation for personalized cancer immunotherapies.
AIM 04Characterize a wide variety of neoantigens displayed by different MHC alleles.
AIM 05Systematically investigate T cell responses to improve anti-cancer treatments.
Skills the Lab Values
microfluidic technologycell cultureprotein purificationhigh-throughput screeningT cell sortingnext-generation sequencingdroplet-based technologydata analysis in immunologybiomechanical force measurement
Output against the department
Publications143bottom 47% of dept.137th of 259
this lab
most publishedleast published
Citations4.1kbottom 21% of dept.204th of 259
this lab
most citedleast cited
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