Harvard University · BiologyLahav Lab
Galit Lahav · Cambridge, Massachusetts
Research Focus
The lab led by Galit Lahav at Harvard Medical School focuses on understanding how the p53 protein, a crucial tumor suppressor, responds to cellular stressors like DNA damage. By studying single cells and their response dynamics, the team aims to uncover the mechanisms that influence cell survival and death. This research is significant for cancer treatment as it may lead to new strategies that enhance the elimination of cancer cells while protecting healthy cells.
p53tumor suppressorDNA damagecellular stressgene expressioncell fateorganotypic modelstranscriptional regulationcancer biology
Research Aims
5AIM 01Investigate how p53 dynamics affect cellular outcomes in response to DNA damage.
AIM 02Determine the role of cell state and spatial environment on p53 responses.
AIM 03Map p53 dynamics to gene expression profiles in individual cells.
AIM 04Assess the effects of altered p53 oscillations on gene expression and cell fate decisions.
AIM 05Explore the relationship between p53 activity and DNA repair efficiency in various cell types.
Skills the Lab Values
cell culturesingle-cell analysisLase-SeqRNA sequencingDNA repair assaysmicroscopyflow cytometryprotein dynamics analysisorganoid culture
Output against the department
Publications108bottom 37% of dept.646th of 1,033
this lab
most publishedleast published
Citations11ktop 34% of dept.352nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.