University of Pennsylvania · BiochemistryThe Methyl Transfer Lab
Fange Liu · Philadelphia, Pennsylvania
Research Focus
Dr. Fange Liu's lab at the University of Pennsylvania focuses on understanding how specific enzymes that modify ribosomal RNA (rRNA) influence the health and functioning of blood stem cells. Particularly, they study a methyltransferase enzyme called DIMT1, which plays crucial roles in both the effectiveness of ribosomes and the expression of genes that are vital for DNA repair and cell survival. The lab aims to uncover how these enzymatic processes affect normal blood cell development and how their dysfunction can lead to disease.
RNA methyltransferaseHematopoiesisDIMT1rRNA modificationsDNA repairHematopoietic stem cellsCell viabilityGene expressionProtein synthesis
Research Aims
3AIM 01Investigate the catalytic role of DIMT1 in HSPC cell viability and protein synthesis.
AIM 02Examine how DIMT1-mediated N266A modification in rRNA controls translation elongation.
AIM 03Explore the structure-function relationships and catalytic mechanisms of DIMT1.
Skills the Lab Values
CRISPR screeningCell cultureIn vitro translation techniquesRNA extractionWestern blottingMolecular cloningFluorescence microscopyBiochemical assaysData analysis using Python
Output against the department
Publications53bottom 8% of dept.369th of 402
this lab
most publishedleast published
Citations2.4kbottom 10% of dept.363rd of 402
this lab
most citedleast cited
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