UTHThe University of Texas Health Science Center at Houston · Microbiology & Immunology
Bacterial Cell Division Laboratory
William Margolin · Houston, Texas
Research Focus
Dr. William Margolin's lab at the University of Texas Health Science Center focuses on understanding how bacteria like E. coli manage to grow and divide. By studying the proteins that form their division machinery, the lab aims to uncover new insights into bacterial cell function and identify potential targets for new antibiotics. Their work combines advanced imaging techniques and molecular genetics to explore the mechanical processes in bacterial life.
bacterial cell divisionE. colidivisomecellular imagingprotein interactionssuper-resolution imagingantibiotic resistancecell wall synthesismolecular genetics
Research Aims
4AIM 01Investigate how protein interactions trigger the assembly of bacterial division machinery.
AIM 02Explore mechanisms regulating the synthesis of the division septum.
AIM 03Study how bacterial cells interface chromosome segregation with division processes.
AIM 04Utilize advanced imaging to observe the dynamic behavior of divisome proteins.
Skills the Lab Values
cell culturebacterial geneticsprotein biochemistrysuper-resolution microscopyin vivo crosslinkingmolecular reconstitutionliquid-liquid phase separationfluorescence microscopy
Output against the department
Publications286top 18% of dept.86th of 486
this lab
most publishedleast published
Citations11ktop 32% of dept.156th of 486
this lab
most citedleast cited
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