University of Washington-Seattle Campus · BiologyTrauma and Neurodegeneration Research Unit
Christopher Dirk Keene · Seattle, Washington
Research Focus
Dr. Christopher Dirk Keene's lab focuses on understanding the complex relationship between traumatic brain injuries and the progression of Alzheimer's disease and related dementias. The lab aims to establish a comprehensive resource that combines brain imaging, neuropathology, and extensive clinical data to improve diagnostics and therapeutic strategies for affected individuals. The research not only emphasizes scientific insights but also prioritizes diversity and inclusion within the research community.
Alzheimer's diseasetraumatic brain injuryneuropathologyneuroimagingchronic traumatic encephalopathydata biorepositorybiostatisticscognitive decline
Research Aims
5AIM 01Expand a nationwide network of brain donors with diverse TBI exposures.
AIM 02Characterize the co-pathology burden related to head trauma exposure patterns.
AIM 03Identify imaging and neuropathology signatures that correlate with cognitive decline.
AIM 04Phenotype vascular pathology associated with traumatic brain injury.
AIM 05Create an open-access data biorepository for research and collaboration.
Skills the Lab Values
MRI imagingneuropathology techniquesclinical data collectiondigital pathology analysisbiostatisticscohort study designdeep phenotypingbioethics in research
Output against the department
Publications540top 7% of dept.68th of 1,033
this lab
most publishedleast published
Citations41ktop 7% of dept.71st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.