Boston University · ChemistryGrinstaff Drug Delivery Lab
Mark W. Grinstaff · Boston, Massachusetts
Research Focus
Dr. Mark W. Grinstaff's lab at Boston University focuses on developing innovative therapeutic strategies to treat cancer and metabolic diseases. Their research is at the intersection of chemistry and biology, utilizing novel biomaterials and RNA technologies to improve drug delivery and efficacy. Key projects include addressing lung cancer through self-amplifying RNA therapies and proposing new treatments for liver disease by restoring lysosome function.
saRNAlung cancerbiomaterialsmetabolic liver diseasedrug delivery
Research Aims
5AIM 01Develop modified saRNA constructs for lung cancer treatment
AIM 02Create acid-activated polymers for lysosomal regeneration in liver diseases
AIM 03Synthesize anticoagulant biomaterials mimicking heparin
AIM 04Evaluate drug-receptor modulation therapies
AIM 05Test sustained release systems for chronic conditions
Skills the Lab Values
cell cultureRNA sequencinganimal modelingbiomaterial synthesisflow cytometry
Output against the department
Publications623top 11% of dept.24th of 216
this lab
most publishedleast published
Citations33ktop 12% of dept.26th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.