University of Utah · GeneticsHuman Genetic Variation Laboratory
Lynn Jorde · Salt Lake City, Utah
Research Focus
Lynn Jorde's lab focuses on understanding human genetic variation and its links to diseases. They study how mutations occur across generations in families from Utah, investigating the relationship between genetic changes, aging, and health outcomes like lifespan and menopause age. The lab also works on developing new methods to analyze genetic data, particularly using whole-genome sequencing and RNA sequencing.
human genetic variationdisease geneticsde novo mutationsDNA repairgenome sequencinglongitudinal studiespedigree analysismultigenerational studiesphenotypic measurements
Research Aims
5AIM 01Investigate the causes of human genetic variation and disease
AIM 02Characterize rates and patterns of de novo mutations in families
AIM 03Examine the influence of DNA repair on mutation rates
AIM 04Develop methods for genome sequence analysis
AIM 05Identify disease-causing genes in large pedigrees.
Skills the Lab Values
whole-genome sequencing (WGS)RNA sequencing (RNA-seq)data analysisgenetic pedigree analysisfunctional analysis in vitrofunctional analysis in vivobioinformatics toolsmolecular biology techniquesphenotypic assessment
Output against the department
Publications367top 21% of dept.55th of 259
this lab
most publishedleast published
Citations77ktop 8% of dept.21st of 259
this lab
most citedleast cited
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