University of Florida · PharmacologyCenter for Age-Related Disease Research
Lina Cui · Gainesville, Florida
Research Focus
Dr. Lina Cui's lab at the University of Florida focuses on developing innovative therapies for age-related diseases, particularly Alzheimer's disease. By using a unique CAR-T cell immunotherapy approach, the lab aims to detect and eliminate senescent cells, which play a significant role in aging and associated disorders. The research could lead to groundbreaking treatments that improve health in the elderly population.
Alzheimer's DiseaseCAR-T Cell TherapyCellular SenescenceSenotherapyNeurodegenerative Disorders
Research Aims
5AIM 01Develop a theranostic CAR T cell platform targeting senescent cells
AIM 02Test the efficacy of different CAR constructs in vitro
AIM 03Establish Alzheimer's disease mouse models
AIM 04Evaluate the activation of CAR T cells in Alzheimer's mice models
AIM 05Assess therapeutic effects through behavioral and imaging assays
Skills the Lab Values
In vitro cell cultureAnimal modeling (mice)Therapeutic protein productionMRI imaging techniquesFlow cytometryGenetic engineeringBehavioral assaysData analysis with PythonChimeric antigen receptor crafting
Output against the department
Publications207top 43% of dept.197th of 462
this lab
most publishedleast published
Citations3.7kbottom 28% of dept.331st of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.