RUThe Rockefeller University · Biology
Brivanlou Lab
Ali H Brivanlou · New York, New York
Research Focus
Dr. Ali H. Brivanlou's lab focuses on using marmoset monkeys to study Huntington's disease, a complex neurodegenerative disorder that affects movement and cognition. The lab aims to create genetic models that mirror human conditions by employing advanced techniques like CRISPR and stem cell technologies. By understanding the molecular basis of Huntington's disease in a primate context, the research seeks to uncover new insights into its causes and how it might be treated.
Huntington's diseasemarmoset modelCRISPRtransgenic animalsneurodegenerative diseasesstem cell biologybehavioral phenotypesgenetic modelsneural circuits
Research Aims
5AIM 01Create transgenic knock-in marmoset pluripotent stem cells.
AIM 02Establish a marmoset model for Huntington's disease with neuron-specific reporters.
AIM 03Correlate molecular changes with behavioral phenotypes in Huntington's disease.
AIM 04Develop advanced IVF protocols for marmosets to improve genetic modeling.
AIM 05Facilitate studies on neural circuits and neurodegenerative disorders.
Skills the Lab Values
CRISPRin vitro fertilization (IVF)pluripotent stem cell cultureanimal behavior assessmentmolecular cloninggenotypingtransgenic animal productionsingle-cell transcriptomicsgenetic screening
Output against the department
Publications213top 30% of dept.310th of 1,033
this lab
most publishedleast published
Citations21ktop 19% of dept.193rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.