University of Rochester · Microbiology & ImmunologyZhu Virology Lab
Yiping Zhu · Rochester, New York
Research Focus
Dr. Yiping Zhu's lab at the University of Rochester focuses on understanding how HIV-1 manipulates cellular processes to enhance its replication and cause neurotoxicity. They study a specific mechanism known as ribosomal frameshifting, which is crucial for producing proteins that support the virus. By investigating how HIV-1 influences modifications of cellular components, the lab aims to uncover new strategies for treating HIV-1 infection and preventing associated cognitive disorders.
HIV-1ribosomal frameshiftingneurotoxicityRNA modificationsviral replication
Research Aims
3AIM 01Elucidate the mechanism by which HIV-1 downregulates yW and DPH modifications.
AIM 02Determine the roles of yW, DPH, and m1acp3 in HIV-1 programmed ribosomal frameshifting and replication.
AIM 03Investigate the roles of yW and DPH in HIV-1-related inflammation and neurotoxicity.
Skills the Lab Values
CRISPR knockout screeningmolecular cloningcell cultureRNA sequencingWestern blotmicroscopygenetic manipulationdata analysisprotein expressionviral assays
Output against the department
Publications171top 39% of dept.187th of 486
this lab
most publishedleast published
Citations3.6kbottom 26% of dept.361st of 486
this lab
most citedleast cited
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