Boston University · BiologyRNA Modifications and Neurodegeneration Lab
Benjamin L Wolozin · Boston, Massachusetts
Research Focus
Dr. Benjamin Wolozin's lab at Boston University Medical Campus focuses on understanding the role of RNA modifications in Alzheimer's disease and related neurodegenerative disorders. They study how changes in specific RNA molecules can contribute to disease progression and aim to identify novel therapeutic targets that could potentially delay or alter the course of Alzheimer's. Through various experimental approaches, the lab investigates the interplay between RNA biology and the pathophysiological processes underlying neurodegeneration.
Alzheimer's diseasetRNA modificationsRNA methylationneurodegenerationepitranscriptomicstau pathologybiomarkersgenetic polymorphismsproteotoxic stress
Research Aims
3AIM 01Analyze the m6A transcriptome in Alzheimer's disease models and human samples.
AIM 02Characterize tRNA modifications and expression patterns in relation to Alzheimer's disease states.
AIM 03Investigate the effects of manipulating tRNA modifications on protein aggregation in neurodegenerative diseases.
Skills the Lab Values
RNA sequencingtRNA analysismethylation assaysmouse modelsbioinformaticsproteomicscell culturegene editing techniqueshuman brain tissue analysis
Output against the department
Publications294top 19% of dept.199th of 1,033
this lab
most publishedleast published
Citations29ktop 12% of dept.123rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.