Pennsylvania State University-Main Campus · ChemistryBollinger Lab
Joseph M Bollinger · University Park, Pennsylvania
Research Focus
Professor Joseph M Bollinger's lab at Penn State University studies metalloenzymes, which are specialized proteins that use metal ions to catalyze important chemical reactions, particularly in drug synthesis. The lab focuses on understanding how these enzymes activate strong chemical bonds and explore their structures to inspire new synthetic methods. Through biochemical and computational approaches, researchers aim to manipulate these enzymes for various applications in medicine and industry.
metalloenzymesenzyme engineeringCH activationbiocatalysisdrug synthesisbiochemical pathwaysprotein structuretransition metalsreactivity control
Research Aims
5AIM 01Investigate how metalloenzymes activate strong chemical bonds.
AIM 02Understand the role of protein architecture in enzyme reactivity.
AIM 03Develop strategies for engineered enzymes in drug synthesis.
AIM 04Explore the use of diverse metal cofactors in enzymatic reactions.
AIM 05Test new reaction pathways using directed evolution strategies.
Skills the Lab Values
enzymatic assay developmentenzyme purificationprotein crystallizationspectroscopic analysiscomputational modelingmetalloprotein characterizationmolecular biology techniquesprotein engineeringreaction kinetics
Output against the department
Publications257top 45% of dept.97th of 216
this lab
most publishedleast published
Citations16ktop 30% of dept.64th of 216
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.