Iowa State University · Microbiology & ImmunologyViral Response Initiative
Jacob Yount · Ames, Iowa
Research Focus
Jacob Yount's lab focuses on understanding how the SARS-CoV-2 virus causes severe damage to the lungs and heart, particularly in individuals with certain immune deficiencies. By studying specific immune responses and inflammatory pathways, they aim to find new ways to prevent and treat COVID-19 complications. Their research involves looking at how different proteins and immune cells contribute to disease severity, which could lead to tailored therapies for vulnerable populations.
SARS-CoV-2COVID-19inflammationimmunodeficienciesCaspase-11lung pathologycardiac pathologytherapeuticsimmune responseneutrophils
Research Aims
5AIM 01Investigate the role of Caspase-11 in SARS-CoV-2 pathogenesis in specific cell types.
AIM 02Examine how immunodeficiencies affect inflammation and disease severity in COVID-19.
AIM 03Identify therapeutic targets for reducing lung and cardiac damage from SARS-CoV-2.
AIM 04Understand the mechanisms of neutrophil recruitment during SARS-CoV-2 infection.
AIM 05Explore the interaction between immune responses and viral pathogenesis in different models.
Skills the Lab Values
PCRcell culturemouse modelsWestern blotin vivo imagingflow cytometrygenetic editingimmunological assaysanimal handlingbiostatistics
Output against the department
Publications154top 42% of dept.206th of 486
this lab
most publishedleast published
Citations5.9kbottom 44% of dept.274th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.