Washington University in St Louis · BiochemistryConoid Structure and Function Lab
Rui Zhang · Saint Louis, Missouri
Research Focus
Dr. Rui Zhang's lab at Washington University focuses on studying the structure and function of a vital organelle, the conoid, in the Toxoplasma gondii parasite. By examining the unique complexities of this structure, the lab aims to unlock insights that could contribute to developing more effective treatments for diseases caused by apicomplexan parasites. This research is crucial as it addresses significant gaps in our understanding of these pathogens, which are responsible for severe human health issues.
Toxoplasma gondiiapicomplexan parasitescytoskeletoncryo-electron microscopyprotein functionmass spectrometrydisease treatment
Research Aims
5AIM 01Identify and characterize the major proteins within the conoid of Toxoplasma gondii.
AIM 02Construct a detailed 3-D model of the conoid structure.
AIM 03Investigate the role of specific proteins in conoid assembly and function.
AIM 04Explore structural similarities and differences with other apicomplexans.
AIM 05Contribute towards improved therapeutic strategies against apicomplexan diseases.
Skills the Lab Values
cell fractionationquantitative mass spectrometrycryo-electron microscopy3-D imagingprotein localizationstructural biologybiochemical assaysmolecular cloningbiophysical techniques
Output against the department
Publications1,431top 1% of dept.4th of 402
this lab
most publishedleast published
Citations109ktop 1% of dept.6th of 402
this lab
most citedleast cited
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