Northeastern University · PharmacologyIon Channel Innovations Lab
Diomedes E. Logothetis · Boston, Massachusetts
Research Focus
Dr. Diomedes E. Logothetis leads a research lab focused on understanding and treating epilepsy and heart diseases, specifically through the study of ion channels, which are crucial for cell communication. The lab works on innovative therapies for Dravet Syndrome, a severe form of epilepsy in children, by investigating how activators of potassium channels can improve cellular function when sodium channels are impaired. Additionally, the lab aims to develop targeted drug therapies to address both atrial fibrillation and thrombosis by manipulating specific ion channels in the heart and blood platelets.
Dravet SyndromeGIRK channelsepilepsyatrial fibrillationdrug designion channelsthrombosis
Research Aims
5AIM 01Investigate the role of GIRK channels in modulating neuronal excitability in epilepsy.
AIM 02Develop targeted therapies for Dravet Syndrome using GIRK channel activators.
AIM 03Utilize computational modeling to design specific inhibitors for GIRK channels.
AIM 04Study the effects of GIRK channel modulation in heart rate variability and atrial fibrillation.
AIM 05Explore the involvement of GIRK channels in platelet activation and thrombosis.
Skills the Lab Values
cell cultureanimal modelselectrophysiology2-photon microscopycomputational drug designEEG monitoringmolecular biology techniquesWestern blotimmunohistochemistry
Output against the department
Publications97bottom 24% of dept.352nd of 462
this lab
most publishedleast published
Citations7.6ktop 47% of dept.219th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.