University of Pennsylvania · Biomedical EngineeringLaboratory of Protein Regulation and Imaging
Mark A Sellmyer · Philadelphia, Pennsylvania
Research Focus
Dr. Mark A. Sellmyer's lab at the University of Pennsylvania focuses on developing innovative methods to control protein functions within living organisms for research in cancer therapy. They are particularly interested in how proteins can be tagged and regulated using small molecules, which allows for advanced imaging techniques to visualize these processes in real time. This work includes creating technologies that can improve treatments, like CAR T-cell therapies, by optimizing how these therapeutic proteins behave inside the body.
PROTACsprotein taggingin vivo imagingCAR T-cell therapysmall molecule drugsfluorescence imagingPET imagingdihydrofolate reductaseprotein regulationdual-modality imaging
Research Aims
5AIM 01Develop small molecule tools for reversible protein regulation.
AIM 02Create imaging-compatible tags for proteins to study their functions.
AIM 03Optimize PROTACs for controlling the expression of therapeutic proteins.
AIM 04Investigate the biodistribution and efficacy of CAR T-cells using imaging techniques.
AIM 05Establish standards for widely adoptable protein regulation technologies.
Skills the Lab Values
cell cultureprotein purificationfluorescence microscopyflow cytometryanimal modelschemical synthesisdrug testingmolecular cloningquantitative imagingbiochemical assays
Output against the department
Publications72bottom 10% of dept.538th of 595
this lab
most publishedleast published
Citations1.6kbottom 10% of dept.533rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.