Columbia University in the City of New York · PhysiologyCalcium Conundrum Lab
Andrew Robert Marks · New York, New York
Research Focus
The research lab led by Dr. Andrew Robert Marks focuses on understanding the muscle symptoms that can arise from statin medications, which are commonly used to treat cardiovascular diseases. They investigate the biological mechanisms behind these symptoms, particularly how alterations in specific calcium channels in muscle tissue may contribute to muscle weakness. The lab also explores potential therapeutic options to reduce these side effects and enhance patient adherence to statin therapy.
Statin therapymuscle symptomsryanodine receptorcalcium signalingtherapeutic interventions
Research Aims
5AIM 01Investigate the mechanisms by which statins induce muscle weakness
AIM 02Explore the role of the RyR1-T4706M mutation in muscle symptoms
AIM 03Identify the binding sites of statins on the ryanodine receptor
AIM 04Assess the potential of ARM210 in stabilizing RyR1 to alleviate muscle symptoms
AIM 05Evaluate patient-derived muscle samples for novel therapeutic insights
Skills the Lab Values
cryogenic electron microscopyelectrophysiological recordingsgene editingmouse model experimentationbiological assays
Output against the department
Publications348top 11% of dept.31st of 286
this lab
most publishedleast published
Citations35ktop 5% of dept.15th of 286
this lab
most citedleast cited
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