University of Louisville · PharmacologyArsenic Exposure and Cancer Lab
J Christopher States · Louisville, Kentucky
Research Focus
Dr. Christopher States' lab at the University of Louisville focuses on understanding how exposure to arsenic leads to cancer, particularly skin cancer. They investigate the role of specific microRNAs in modifying gene expression and causing chromosomal instability, which is a significant factor in tumor development. The lab develops new models to study these effects and aims to fill critical knowledge gaps in cancer etiology related to environmental exposures.
arsenicmicroRNAskin cancercarcinogenesischromosomal instability
Research Aims
3AIM 01Determine how miR-186 overexpression causes chromosomal instability in skin cells.
AIM 02Characterize a new cell model for studying arsenic-induced skin cancer.
AIM 03Investigate the role of specific miRNAs in transforming skin cells affected by arsenic exposure.
Skills the Lab Values
cell culturekaryotypingRNA sequencinggene expression analysismolecular cloning
Output against the department
Publications181top 50% of dept.230th of 462
this lab
most publishedleast published
Citations5.8kbottom 42% of dept.269th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.