University of Arizona · PharmacologyThe TDP-43 Nexus
Xinglong Wang · Tucson, Arizona
Research Focus
Dr. Xinglong Wang's research lab at the University of Arizona focuses on understanding how the TDP-43 protein contributes to neurodegenerative diseases like ALS and Alzheimer's disease. By studying the interactions between TDP-43 and mitochondria, the lab investigates how changes in TDP-43 behavior might lead to neuron damage. This research aims to uncover critical mechanisms that could potentially reveal new therapies for these debilitating conditions.
TDP-43amyotrophic lateral sclerosisAlzheimer's diseaseliquid-liquid phase separationmitochondrial dysfunctionneurodegenerationcell modelsneuronal lossdisease progression
Research Aims
5AIM 01Investigate how TDP-43 undergoes liquid-liquid phase separation in neurons.
AIM 02Examine the relationship between TDP-43 localization and mitochondrial function.
AIM 03Assess the impact of TDP-43 LLPS on neuronal survival and health.
AIM 04Explore the mechanisms of TDP-43-related neurodegeneration in animal models.
AIM 05Identify potential therapeutic targets by understanding TDP-43 proteinopathy.
Skills the Lab Values
cell culturemouse modelsWestern blotRNA sequencingimmunofluorescence microscopybiochemical assaysdata analysisexperimental designbioenergetics measurements
Output against the department
Publications210top 41% of dept.191st of 462
this lab
most publishedleast published
Citations21ktop 16% of dept.76th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.