Northwestern University · BiologyMitchell Ciliary Lab
Brian Joseph Mitchell · Evanston, Illinois
Research Focus
Dr. Brian Joseph Mitchell's lab at Northwestern University focuses on understanding primary ciliary dyskinesia (PCD), a genetic disorder that impacts respiratory health and other bodily functions. The research uses a unique model of ciliated cells from Xenopus embryos to explore how cilia develop and function. By identifying and characterizing new genes involved in PCD, the lab aims to improve diagnostic methods and enhance our understanding of this complicated condition.
primary ciliary dyskinesiaciliary functiongenetic screeningCRISPR/Cas9gene characterization
Research Aims
5AIM 01Identify novel genes that cause primary ciliary dyskinesia.
AIM 02Characterize ciliary function using Xenopus embryonic cells.
AIM 03Develop quantifiable assays for ciliated cells.
AIM 04Enhance diagnostic tools for PCD patients.
AIM 05Establish subclasses of PCD based on ciliary defects.
Skills the Lab Values
CRISPR/Cas9gene cloningcell cultureembryonic model systemsmicroscopy