Stanford University · GeneticsRibosomal Protein Disorders Lab
Maria Barna · Stanford, California
Research Focus
Dr. Maria Barna's lab at Stanford University focuses on understanding how mutations in ribosomal proteins lead to specific blood and developmental disorders, such as Diamond-Blackfan Anemia (DBA). By examining the translation of genes within blood cells, they aim to uncover why certain tissues are affected by these mutations. The research could improve our knowledge of these diseases and lead to new treatments.
Diamond-Blackfan Anemiaribosomopathiestranslational controlhematopoietic dysfunctionhigh throughput screening
Research Aims
3AIM 01Investigate the translational landscape of gene expression in DBA disease models.
AIM 02Identify the role of translation factor 4E-BP1 in mRNA specificity related to ribosomopathies.
AIM 03Screen for small molecules that can activate translational control for potential DBA therapies.
Skills the Lab Values
ribosome profilingcell culturemouse modelshigh throughput screeningmolecular cloning
Output against the department
Publications89bottom 26% of dept.191st of 259
this lab
most publishedleast published
Citations10ktop 50% of dept.129th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.