University of Pennsylvania · NeuroscienceKolson Lab
Dennis Larry Kolson · Philadelphia, Pennsylvania
Research Focus
Dr. Dennis Kolson's lab at the University of Pennsylvania focuses on understanding and preventing brain injury related to HIV infection. The lab investigates how combining existing HIV therapies with new neuroprotective agents may reduce neurological damage and improve cognitive function in patients. Their groundbreaking work uses Rhesus macaques to explore the potential of a drug called dimethyl fumarate to enhance brain recovery following early HIV infection.
HIVbrain injuryneuroprotectiondimethyl fumaratecARToxidative stressneuroinflammationSIV
Research Aims
3AIM 01Investigate the effects of dimethyl fumarate on oxidative injury in the brain during acute SIV infection.
AIM 02Evaluate the impact of concurrent DMF and cART therapy on neuroinflammation and neuronal recovery.
AIM 03Assess the patterns of immune cell infiltration and activation in the brain during SIV infection.
Skills the Lab Values
animal surgerycell cultureimmunohistochemistryPCRflow cytometryRNA analysisWestern blottingbehavioral assays
Output against the department
Publications206top 36% of dept.240th of 671
this lab
most publishedleast published
Citations11ktop 35% of dept.238th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.