University of Rhode Island · PharmacologyThe Mitochondrial Wellness Lab
Giuseppe Coppotelli · Kingston, Rhode Island
Research Focus
Dr. Giuseppe Coppotelli's lab at the University of Rhode Island focuses on the role of mitochondrial DNA (mtDNA) mutations in aging and related diseases. They are particularly interested in how these mutations vary across different tissues and how lifestyle factors, like exercise and calorie restriction, influence these changes. By studying mouse models, the lab aims to uncover mechanisms that could help develop interventions to improve health as we age.
mitochondrial DNAaginglifestyle interventionsmtDNA mutationsexercisecaloric restrictionhealthspanneurodegenerative disorderstissue-specific accumulation
Research Aims
3AIM 01Investigate tissue-specific clearance of mtDNA mutations.
AIM 02Examine how different tissues accumulate mtDNA mutations and their responses to lifestyle changes.
AIM 03Determine the effects of post-embryonic mtDNA mutations on aging phenotypes.
Skills the Lab Values
genetic approachesmouse modelstissue culturegermline mutation analysissomatic mutation detectionmolecular cloningPCRoxidative stress assessmentdata collection and analysisexperimental design
Output against the department
Publications52bottom 8% of dept.427th of 462
this lab
most publishedleast published
Citations3.1kbottom 24% of dept.351st of 462
this lab
most citedleast cited
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