University of Utah · BiologyHale Lab
Jeffrey Scott Hale · Salt Lake City, Utah
Research Focus
Dr. Jeffrey Scott Hale's lab focuses on understanding how CD4+ T cells respond to influenza infections. The research explores the mechanisms by which prior exposures to antigens, either through vaccination or infection, shape T cell responses in the lungs. By investigating T cell receptor signaling and epigenetic programming, the lab aims to improve vaccination strategies against influenza, potentially leading to longer-lasting immune protection.
CD4+ T cellsinfluenzaimmunizationTCR signalingepigeneticsmemory T cellsimmune responsevaccination strategies
Research Aims
2AIM 01Determine the relationship between TCR signal strength and CD4+ T cell differentiation in the lung.
AIM 02Define the role of epigenetic programming in driving secondary T cell responses to influenza.
Skills the Lab Values
PCRcell cultureflow cytometrymolecular cloningepigenetic analysisanimal modelsimmunological assaysWestern blottingRNA sequencing
Output against the department
Publications38bottom 6% of dept.966th of 1,033
this lab
most publishedleast published
Citations879bottom 4% of dept.994th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.