WMCWeill Medical College of Cornell University · Microbiology & Immunology
Tuberculosis Metabolism Research Unit
Sabine Ehrt · New York, New York
Research Focus
Dr. Sabine Ehrt's lab focuses on understanding the role of M. tuberculosis (Mtb) and its metabolism during infection to aid in developing new tuberculosis drugs. The research particularly examines how different environments within the human body affect Mtb's survival and growth, especially regarding its carbon source requirements. By studying drug targets in animal models that mirror human conditions, her lab aims to find innovative therapeutic approaches to combat tuberculosis, a significant global health threat.
M. tuberculosiscarbon metabolismtuberculosisdrug developmentanimal modelsglycolysisgluconeogenesisinfectious diseasepathology
Research Aims
5AIM 01Investigate the carbon metabolism of M. tuberculosis during infection.
AIM 02Evaluate the importance of specific enzymes in M. tuberculosis growth and survival.
AIM 03Test drug targets using genetically modified strains of M. tuberculosis.
AIM 04Analyze different environmental conditions affecting M. tuberculosis in animal models.
AIM 05Explore the potential for new drug development against tuberculosis.
Skills the Lab Values
PCRanimal modelscell culturegenetic engineeringmutant screeningbiochemical assaysmicrobial geneticspathogen-host interaction studiesconditional knockdown techniques
Output against the department
Publications169top 39% of dept.189th of 486
this lab
most publishedleast published
Citations16ktop 25% of dept.120th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.