Texas Tech University Health Sciences Center · Microbiology & ImmunologyLung Health and HIV Research Laboratory
Sharilyn Almodovar · Lubbock, Texas
Research Focus
Dr. Sharilyn Almodovar's lab investigates how the HIV virus affects the lungs and heart, particularly focusing on a condition known as Pulmonary Hypertension that can occur in people living with HIV. By studying how specific HIV proteins and genetic differences influence lung blood vessel function, the lab aims to uncover mechanisms of disease and potential new treatments. Their research combines cutting-edge techniques with both human cells and animal models to better understand the impact of HIV on lung health.
HIVPulmonary HypertensionVascular RemodelingEndothelial CellsTranscriptomicsEpigenomicsCXCR4Animal ModelsHuman CellsTherapeutic Advances
Research Aims
5AIM 01Investigate the effects of HIV on pulmonary vascular cells
AIM 02Determine how specific HIV polymorphisms contribute to vascular disease
AIM 03Analyze the signaling pathways involved in HIV-related pulmonary hypertension
AIM 04Explore the transcriptomic and epigenomic changes in lung cells due to HIV
AIM 05Develop new therapeutic strategies for preventing lung diseases in people with HIV
Skills the Lab Values
Cell CultureSingle-cell RNA Sequencing (scRNA-seq)Single-cell ATAC Sequencing (scATAC-seq)Molecular CloningLaboratory Animal Models (hu-mice)ImmunofluorescenceFlow CytometryWestern BlottingGenetic Polymorphism AnalysisExperimental Design
Output against the department
Publications62bottom 16% of dept.406th of 486
this lab
most publishedleast published
Citations915bottom 5% of dept.461st of 486
this lab
most citedleast cited
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