University of California-Irvine · PhysiologyBotulinum Neurotoxin Research Lab
Rongsheng Jin · Irvine, California
Research Focus
Dr. Rongsheng Jin's lab at UC Irvine focuses on understanding a type of bacterial toxin known as botulinum neurotoxins (BoNTs), which can cause a serious illness called botulism. The lab is particularly interested in a specific complex associated with these toxins, aiming to explore its structure and how it functions in order to develop new treatments for botulism and similar bacterial infections. They utilize advanced techniques to study how these toxins interact with proteins and receptors in the body, ultimately helping improve public health.
botulinum neurotoxinsbacterial toxinstoxin complexescryogenic electron microscopyX-ray crystallographypathogenesistherapeuticsClostridiumbiophysics
Research Aims
3AIM 01Characterize the mechanisms underlying the assembly of the OrfXs/P47 complex.
AIM 02Determine the structures of the OrfXs/P47 complex and sub-complexes.
AIM 03Investigate the potential regulatory factors and receptors of the OrfXs/P47 complex.
Skills the Lab Values
cryogenic electron microscopyX-ray crystallographysite-directed mutagenesisprotein purificationbiochemical assayscell culturerecombinant DNA technologyprotein-protein interaction analysis
Output against the department
Publications157top 47% of dept.135th of 286
this lab
most publishedleast published
Citations4.7kbottom 39% of dept.174th of 286
this lab
most citedleast cited
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