Northwestern University · Microbiology & ImmunologyWang Lab
Chyung-Ru Wang · Evanston, Illinois
Research Focus
Chyung-Ru Wang's research lab at Northwestern University investigates how a specific type of immune cell, called Group 1 CD1-restricted T cells, interacts with lipid antigens during infections like tuberculosis. They are particularly interested in how conditions like hyperlipidemia (high levels of fat in the blood) can affect these T cells and their memory responses to infections. Their findings may lead to new treatments for autoimmune diseases and improved vaccines.
T cell immunityGroup 1 CD1hyperlipidemiaMycobacterium tuberculosisautoimmune diseasesvaccinationlipid antigensmemory T cells
Research Aims
5AIM 01Investigate the effect of hyperlipidemia on T cell responses to Mycobacterium tuberculosis.
AIM 02Explore the properties of memory MA/CD1b-specific T cells following vaccination.
AIM 03Compare T cell responses elicited by different vaccination strategies.
AIM 04Identify molecular mechanisms regulating CD1-restricted T cells during infections.
AIM 05Assess the potential of targeting lipid-specific T cells for vaccine development.
Skills the Lab Values
transgenic mouse modelscell cultureimmunological assaysin vivo imagingPCRWestern blotflow cytometrynanoparticle drug deliverydata analysis using R
Output against the department
Publications138top 47% of dept.227th of 486
this lab
most publishedleast published
Citations9.1ktop 40% of dept.194th of 486
this lab
most citedleast cited
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