University of Notre Dame · BiologyHyde Lab
David R Hyde · Notre Dame, Indiana
Research Focus
Dr. David R. Hyde's lab at the University of Notre Dame focuses on understanding why zebrafish can regenerate retinal neurons after acute damage, but not after chronic damage. This research is crucial for developing therapies to treat human vision loss caused by gradual retinal degeneration. Through innovative techniques, the lab explores the roles of retinal cells and immune responses in the regeneration process, aiming to leverage these insights for clinical applications.
retinal regenerationzebrafishMuller gliachronic retinal damagemicrogliagene expression analysisvisual impairmentneuroinflammation
Research Aims
3AIM 01Determine the potential of chronic zebrafish models to regenerate lost cones after induced stimuli.
AIM 02Analyze gene expression and chromatin accessibility in Muller glia and microglia between acute and chronic retinal damage.
AIM 03Test the roles of candidate regulators identified in gene expression analyses to understand retinal regeneration.
Skills the Lab Values
ATAC-seqsingle-nuclear RNA sequencingbioinformaticszebrafish modelsmolecular cloningcell cultureCRISPR/Cas technologygene expression profilinginjection techniques
Output against the department
Publications171top 39% of dept.400th of 1,033
this lab
most publishedleast published
Citations8.8ktop 43% of dept.447th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.