Georgia State University · ChemistryThe Arenavirus Assembly Lab
Ming Luo · Atlanta, Georgia
Research Focus
Dr. Ming Luo's lab at Georgia State University focuses on understanding the assembly and structure of arenaviruses, such as the lymphocytic choriomeningitis virus (LCMV), which can pose serious public health threats. The team employs advanced techniques like cryo-electron tomography to visualize viral structures and explore how these pathogens assemble and interact at the molecular level. Their research aims to contribute to the development of vaccines and antiviral agents to combat viral outbreaks.
arenavirusLymphocytic choriomeningitis viruscryo-electron tomographyviral assemblyviral structures
Research Aims
3AIM 01Investigate the architectural organization of arenaviruses using cryo-electron tomography.
AIM 02Define the protein-RNA interactions in LCMV nucleocapsids at atomic resolution.
AIM 03Explore the assembly mechanisms of LCMV virion and nucleocapsid for better understanding of viral pathogenicity.
Skills the Lab Values
Cryo-electron microscopyCryo-electron tomographyMolecular modelingDensity gradient centrifugationCell cultureProtein purificationRNA extractionWestern blottingGenomic sequencing
Output against the department
Publications278top 41% of dept.89th of 216
this lab
most publishedleast published
Citations3.4kbottom 25% of dept.162nd of 216
this lab
most citedleast cited
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