Harvard University · Microbiology & ImmunologyLaboratory of Protein Homeostasis
Vladimir Denic · Cambridge, Massachusetts
Research Focus
Dr. Vladimir Denic's lab at Harvard University focuses on understanding how proteins are formed and broken down in cells. The research explores a new chaperone system that helps build an important protein called eEF1A, which is essential for protein synthesis. The lab also investigates how cells manage damaged organelles through a process called selective autophagy, linking protein production and degradation. Together, this work aims to uncover the mechanisms that maintain protein balance and health in cells, which has implications for aging and diseases.
protein biogenesisprotein degradationselective autophagyeEF1Achaperone proteinscellular stress responsesquality controlgenetic screeningyeast modelshuman cell culture
Research Aims
5AIM 01Investigate how the eFOLD chaperone system assists in the formation of eEF1A.
AIM 02Explore the mechanisms of selective autophagy for degrading damaged organelles.
AIM 03Identify the physiological cues that trigger protein biogenesis and degradation pathways.
AIM 04Uncover the molecular signals that lead to the recognition and degradation of misfolded proteins.
AIM 05Research the evolutionary conservation of protein homeostasis mechanisms between yeast and human cells.
Skills the Lab Values
cell culturegenetic screeningbiochemical purification3D microscopyprotein structure-function analysistheoretical modelingautophagosome assayheat shock response studiesbiochemical reconstitutionquantitative microscopy
Output against the department
Publications50bottom 11% of dept.431st of 486
this lab
most publishedleast published
Citations5.4kbottom 39% of dept.295th of 486
this lab
most citedleast cited
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