Pennsylvania State University-Main Campus · NeuroscienceNeurodegeneration and Cell Vulnerability Lab
Anirban Paul · University Park, Pennsylvania
Research Focus
Dr. Anirban Paul's research lab focuses on understanding how different types of brain cells are affected by Alzheimer's disease (AD) and aging. The lab explores how certain cell types might be more vulnerable to AD and why others seem to resist damage. By studying these cell types in mouse models, they aim to uncover the molecular and genetic factors that contribute to the risk of developing AD, potentially leading to new insights for treatment and prevention.
Alzheimer's diseaseagingneurodegenerationcell-type specificitytranscriptomicssynaptic communicationanimal modelslight-sheet microscopyRNA sequencingglycosylation codes
Research Aims
3AIM 01Investigate how different subclasses of brain cells respond to Alzheimer's disease and aging.
AIM 02Examine the structural changes in excitatory and inhibitory neurons during the progression of Alzheimer's disease.
AIM 03Identify how specific glycosylation patterns in cells influence their vulnerability to Alzheimer's disease.
Skills the Lab Values
single-cell RNA sequencing (scRNA-Seq)light-sheet microscopymultiplexed RNA in situ hybridizationmouse modelsbioinformaticsgene expression analysisdata visualizationhistological techniquesmolecular biologycell culture
Output against the department
Publications87bottom 27% of dept.492nd of 671
this lab
most publishedleast published
Citations1.5kbottom 9% of dept.609th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.