Columbia University in the City of New York · BiologyPellizzoni Lab
Livio Pellizzoni · New York, New York
Research Focus
Dr. Livio Pellizzoni's lab focuses on understanding spinal muscular atrophy (SMA), a genetic disease that leads to motor neuron deterioration and muscle atrophy. The research aims to uncover the underlying mechanisms of SMA and identify new therapeutic approaches to improve treatment outcomes for affected individuals. By studying RNA-mediated processes and developing potential drug combinations, the lab seeks to address significant challenges in the management of SMA.
Spinal Muscular AtrophyRNA SplicingMotor Neuron DiseaseNeuroinflammationGene TherapyGlutamatergic SystemNeuromuscular JunctionMicrogliaSMN Protein
Research Aims
3AIM 01Establish conservation of RNA-mediated mechanisms in SMA across mouse models.
AIM 02Determine therapeutic potential of pharmacological approaches to enhance neurotransmission in SMA.
AIM 03Investigate the role of microglial activation in SMA pathology.
Skills the Lab Values
RNA sequencingAAV-mediated gene deliverymouse modelspharmacological testingelectrophysiologycell culturebehavioral assaysimmunohistochemistrymolecular biology techniques
Output against the department
Publications84bottom 26% of dept.763rd of 1,033
this lab
most publishedleast published
Citations7.2kbottom 49% of dept.522nd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.