University of North Carolina at Chapel Hill · Microbiology & ImmunologyHIV Antibody Development Unit
Kristina De Paris · Chapel Hill, North Carolina
Research Focus
Dr. Kristina De Paris's lab at UNC Chapel Hill focuses on understanding how to induce effective antibodies against HIV, particularly in infants. Their research investigates the roles of vaccine components and the host’s microbiota in the development of broadly neutralizing antibodies (bNAbs), which are essential for preventing HIV infections. By exploring these mechanisms, the lab aims to enhance vaccine strategies for better immune responses.
HIVbroadly neutralizing antibodiesvaccine designmicrobiotaimmunology
Research Aims
3AIM 01Identify early determinants of bNAb precursor induction related to vaccine adjuvants.
AIM 02Examine the role of host microbiota in shaping infant immune responses.
AIM 03Develop computational models to predict bNAb development based on immune and microbiome interactions.
Skills the Lab Values
PCRcell culturebioinformaticsdata modelinganimal modelsmolecular profilingsystems biologystatistical analysisimmunization techniquesmetagenomics
Output against the department
Publications115bottom 43% of dept.275th of 486
this lab
most publishedleast published
Citations840bottom 5% of dept.463rd of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.