Duke University · Biomedical EngineeringCalcification Insights Lab
Lars J Grimm · Durham, North Carolina
Research Focus
Dr. Lars J. Grimm's research lab focuses on improving breast cancer screening processes, particularly how to better interpret mammographic calcifications. The team aims to distinguish between benign and malignant conditions through innovative imaging and biomarker analysis over time. By leveraging data from multiple mammograms and tissue samples, their goal is to reduce unnecessary biopsies and overtreatment of patients diagnosed with early-stage breast cancer.
breast cancermammographybiomarkerscalcificationsdiagnostic imagingearly-stage breast canceroverdiagnosiscomputer-assisted diagnosispatient outcomespublic health
Research Aims
3AIM 01Develop a static model of breast calcifications to improve clinical performance of mammography screening.
AIM 02Create a dynamic model of breast calcifications to predict histopathology and DCIS prognosis.
AIM 03Combine dynamic calcification models with tissue-based biomarkers to delineate prognosis for DCIS.
Skills the Lab Values
mammographybiopsy techniquescomputer-assisted diagnosisdata collection and managementbiomedical imaging analysisstatistical modelingtissue sample analysisdatabase managementclinical trial designpatient monitoring
Output against the department
Publications284top 34% of dept.200th of 595
this lab
most publishedleast published
Citations5.0kbottom 38% of dept.368th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.