Rutgers University-Newark · BiologyDNA Modifications and Intestinal Health Lab
Jean-Pierre Etchegaray · Newark, New Jersey
Research Focus
Dr. Jean-Pierre Etchegaray's lab at Rutgers focuses on understanding how DNA modifications affect intestinal health. Specifically, they study how a family of enzymes called TETs can modify DNA in intestinal cells, impacting their response to environmental stressors like gut bacteria and infections. Their research aims to uncover mechanisms that maintain intestinal cell function and protect against diseases such as colitis.
DNA methylationintestinal healthTET enzymesgene regulationimmune response
Research Aims
5AIM 01Investigate the role of TET3 in intestinal epithelial cells
AIM 02Explore how microbiota and stressors affect DNA methylation
AIM 03Determine the impact of TET-mediated DNA oxidation on gene expression
AIM 04Analyze the protective functions of TET3 against inflammation
AIM 05Develop mouse models to study intestinal cell responses to stressors.
Skills the Lab Values
mouse modelsgenome-wide approachesgenetic manipulationtranscriptional profilingimmunohistochemistry
Output against the department
Publications58bottom 14% of dept.885th of 1,033
this lab
most publishedleast published
Citations4.7kbottom 36% of dept.656th of 1,033
this lab
most citedleast cited
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