Icahn School of Medicine at Mount Sinai · BiologyDubois Lab
Nicole Dubois · New York, New York
Research Focus
Dr. Nicole Dubois' research lab focuses on understanding how the heart's basic building blocks, known as sarcomeres, are formed during development and how RNA-binding proteins like DDX3X play crucial roles in heart function and disease. By studying the mechanisms that lead to congenital heart defects and cardiomyopathies, the lab aims to uncover new therapeutic targets for heart diseases. They utilize cutting-edge technologies to explore both the structural and functional aspects of heart development.
cardiac sarcomerescongenital heart defectsRNA-binding proteinsDDX3Xheart developmentpluripotent stem cellscellular mechanismsCRISPRsarcomerogenesisRNA regulation
Research Aims
5AIM 01Investigate the biophysical properties of Z-bodies during early heart development.
AIM 02Identify the molecular mechanisms of Z-body formation and their role in sarcomerogenesis.
AIM 03Uncover the functional targets of the RNA-binding protein DDX3X in cardiac development.
AIM 04Determine the cellular consequences of DDX3X deficiency in embryonic heart development.
AIM 05Elucidate the link between DDX3X mutations and congenital heart disease using patient-derived cells.
Skills the Lab Values
CRISPRmouse modelshuman pluripotent stem cell differentiationsuper-resolution microscopytime-lapse microscopyfluorescence recovery after photobleachingtransmission electron microscopymolecular biology techniquesdata analysisbiophysical characterization
Output against the department
Publications79bottom 23% of dept.795th of 1,033
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.708th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.