WMCWeill Medical College of Cornell University · Biology
Cellular Aging Research Lab
Jessica K Tyler · New York, New York
Research Focus
Dr. Jessica K Tyler's lab at Weill Medical College focuses on understanding how certain biological processes can extend the lifespan of cells. Using yeast as a model organism, the lab investigates how autophagy—an essential process for cellular maintenance—contributes to the effects of various anti-aging interventions. Their research combines genetic manipulations and dietary interventions to reveal insights into the molecular mechanisms behind aging, which could have implications for improving health in humans.
autophagyreplicative lifespanyeastagingdietary interventionsgenetic manipulationanti-agingcell aging
Research Aims
5AIM 01Investigate the role of autophagy in extending yeast replicative lifespan.
AIM 02Identify molecular targets of anti-aging interventions in yeast.
AIM 03Evaluate the effects of genetic and dietary interventions on lifespan extension.
AIM 04Study the mechanisms of autophagy in aging processes.
AIM 05Explore the extrapolation of findings from yeast to metazoans.
Skills the Lab Values
yeast culturinggenetic manipulationPCRWestern blotautophagy assayscell viability assaysRNA isolationdata analysisbiochemical assays
Output against the department
Publications164top 40% of dept.418th of 1,033
this lab
most publishedleast published
Citations9.3ktop 41% of dept.421st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.