University of Michigan-Ann Arbor · GeneticsThe Xist Exploration Lab
Sundeep Kalantry · Ann Arbor, Michigan
Research Focus
Dr. Sundeep Kalantry's lab at the University of Michigan focuses on understanding how mammals balance gene expression from their sex chromosomes, particularly how females with two X chromosomes and males with one equalize their gene expression. The research investigates the role of a specific RNA called Xist in this process and explores alternative mechanisms that may have evolved over time, using mouse models to uncover these genetic insights. This work has broad implications for understanding genetic regulation and potential health impacts.
dosage compensationX chromosomeXistgene expressiondevelopmentevolutionmouse modelsRNAgenetic regulationtranscriptomics
Research Aims
5AIM 01Determine the role of Xist RNA in dosage compensation during development.
AIM 02Investigate the necessity of X-inactivation for equalizing X-linked gene expression.
AIM 03Test ancestral X chromosome-encoded factors in mouse models lacking Xist.
AIM 04Analyze dosage compensation in Xist-null female mouse embryos.
AIM 05Define evolutionary mechanisms behind mammalian sex chromosome dosage compensation.
Skills the Lab Values
PCRRNA sequencingembryonic stem cell culturechromatin profilingbioinformaticsmouse breedinggenetic modelinggene expression analysistranscriptome analysiscell differentiation techniques
Output against the department
Publications67bottom 16% of dept.217th of 259
this lab
most publishedleast published
Citations2.8kbottom 15% of dept.219th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.