EUEmory University · Pharmacology
Thota Lab
Thota Ganesh · Atlanta, Georgia
Research Focus
Dr. Thota Ganesh's lab at Emory University focuses on developing new treatments for Alzheimer's disease, particularly through targeting a specific receptor involved in brain inflammation. They are working on small-molecule drugs that can potentially slow down the progression of Alzheimer's by reducing neuroinflammation and improving cognitive function. The research aims to create effective therapies that offer hope to the millions affected by this debilitating condition.
Alzheimer's diseaseneuroinflammationEP2 receptordrug developmentcognition enhancementanimal modelssmall molecule therapybiomarkersFDA drug approval
Research Aims
5AIM 01Develop small-molecule antagonists that target the EP2 receptor to mitigate Alzheimer's disease progression.
AIM 02Assess the pharmacokinetics and pharmacodynamics of lead EP2 antagonists in mouse models.
AIM 03Investigate the impact of EP2 receptor antagonism on neuroinflammation and cognitive function.
AIM 04Conduct drug development studies to ensure safety and efficacy for potential clinical use.
AIM 05Identify and validate biomarkers associated with Alzheimer's disease pathology in blood and brain tissue.
Skills the Lab Values
mouse modelsdrug kinetics analysisCerebrospinal Fluid (CSF) analysisbiomarker evaluationin vivo pharmacologymolecular biology techniquesprostaglandin receptor assaysanimal handling techniquesclinical trial design
Output against the department
Publications114bottom 31% of dept.318th of 462
this lab
most publishedleast published
Citations3.4kbottom 26% of dept.341st of 462
this lab
most citedleast cited
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