Stanford University · BiologyCystic Fibrosis Therapeutics Lab
Ron R Kopito · Stanford, California
Research Focus
Dr. Ron R. Kopito's lab is focused on understanding and improving therapies for cystic fibrosis, a serious genetic lung disease. They are particularly interested in how certain proteins are manipulated inside cells to aid their proper function. A major part of their research investigates the ways that cell mechanisms can fail to support these proteins, especially in cases where current treatments do not work.
cystic fibrosisCFTRribosome quality controlUFMylationCRISPRgene therapytherapeutic targetsprotein synthesisdrug discovery
Research Aims
3AIM 01Identify genes involved in CFTR stability using genome-wide CRISPR analyses.
AIM 02Test potential drug targets for CFTR variants that do not respond to existing therapies.
AIM 03Understand the role of UFMylation in ribosome quality control for proteins synthesized at the endoplasmic reticulum.
Skills the Lab Values
CRISPR screeningmolecular cloningcell culturegenome editingprotein assaysWestern blottingRNA extractionimmunofluorescence microscopydrug testing methodologiesstructural biology
Output against the department
Publications159top 42% of dept.436th of 1,033
this lab
most publishedleast published
Citations28ktop 13% of dept.131st of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.