Michigan State University · ChemistryHuang Lab
Xuefei Huang · East Lansing, Michigan
Research Focus
Dr. Xuefei Huang's lab at Michigan State University focuses on developing innovative vaccines to combat diseases caused by bacteria, particularly pertussis and antibiotic-resistant pathogens. The lab combines synthetic chemistry and microbiology to design carbohydrate-based vaccines that can generate strong immune responses. The research aims to understand the structures of sugar molecules on bacterial surfaces and how they can be utilized to create effective vaccine candidates.
vaccinespertussisBordetella pertussispoly-N-acetylglucosamineantimicrobial resistanceglycanssynthetic chemistrymicrobiologyimmunogenicity
Research Aims
3AIM 01Develop complex carbohydrate antigens for pertussis vaccine.
AIM 02Generate and characterize synthetic libraries of PNAG glycans.
AIM 03Evaluate vaccine efficacy in animal models to combat antibiotic-resistant bacteria.
Skills the Lab Values
synthetic oligosaccharide synthesisbacterial cultureanimal models (mice/rabbits)immunological assaysantibody characterizationhigh-performance liquid chromatographygel electrophoresisprotein conjugation techniquesdata analysis (statistics)
Output against the department
Publications371top 30% of dept.64th of 216
this lab
most publishedleast published
Citations11ktop 44% of dept.94th of 216
this lab
most citedleast cited
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