Thomas Jefferson University · Microbiology & ImmunologyAutoimmune Disease Metabolism Lab
Ziaur Rahman · Philadelphia, Pennsylvania
Research Focus
Dr. Ziaur Rahman's lab at Thomas Jefferson University focuses on understanding autoimmune diseases, particularly systemic lupus erythematosus (SLE). His research investigates how specific metabolic pathways and regulatory molecules in B cells contribute to the development of autoreactive cells and disease progression. The lab aims to identify potential therapeutic targets to improve treatments for SLE and related conditions.
systemic lupus erythematosusautoreactive B cellspyrimidine metabolismmiR-21metabolic reprogramming
Research Aims
3AIM 01Identify the mechanisms of pyrimidine metabolism in autoreactive B cells in SLE.
AIM 02Investigate how miR-21 regulation affects B cell activation and autoantibody production.
AIM 03Determine the role of IRF7 signaling in autoreactive B cell development.
Skills the Lab Values
flow cytometrymouse modelsRNA sequencingcell culturebiochemical assays
Output against the department
Publications72bottom 22% of dept.379th of 486
this lab
most publishedleast published
Citations2.2kbottom 14% of dept.420th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.