Yale University · NeuroscienceThe Opioid-HIV Interface Lab
Yuval Kluger · New Haven, Connecticut
Research Focus
Dr. Yuval Kluger’s lab at Yale University focuses on understanding how opioid use disorder (OUD) and HIV affect the brain’s cellular functions. The team utilizes advanced techniques to analyze brain tissue samples to uncover molecular changes and interactions between these two conditions, which are currently not well understood. Their goal is to identify potential targets for new treatments that can address the combined impact of OUD and HIV on the nervous system.
HIVopioid use disordersingle-nucleus transcriptomicsmachine learningspatial transcriptomics
Research Aims
4AIM 01Mine SCORCH Consortium data to create a catalog of differentially expressed genes in HIV and OUD.
AIM 02Apply neural networks to distinguish batch effects and disease-related variations.
AIM 03Utilize spatial transcriptomics to identify cell-cell interactions and expression patterns.
AIM 04Leverage external datasets to characterize differential expression and underlying mechanisms.
Skills the Lab Values
single-nucleus isolationRNA sequencingdifferential expression analysismachine learningspatial transcriptomicsneural network modeling
Output against the department
Publications371top 17% of dept.115th of 671
this lab
most publishedleast published
Citations23ktop 18% of dept.118th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.