Columbia University in the City of New York · BiologyHudson Immunology Lab
Krystalyn E Hudson · New York, New York
Research Focus
Dr. Krystalyn Hudson's research focuses on understanding autoimmune hemolytic anemia (AIHA), a condition where the immune system mistakenly targets and destroys red blood cells. The lab investigates how the immune system achieves tolerance to red blood cell antigens and what goes wrong in AIHA. They use innovative mouse models to explore the interplay between different T cell populations and signaling molecules involved in immune responses, aiming to develop better strategies for prevention and treatment.
AIHAimmune tolerancered blood cellsautoantibodiesT cell populationscheckpoint inhibitorsimmunotherapyautoimmunitysex and age factors
Research Aims
5AIM 01Investigate how immune tolerance to red blood cells is established and disrupted.
AIM 02Determine the roles of different T cell populations in mediating immune responses to red blood cell antigens.
AIM 03Identify key signaling pathways involved in T cell tolerization and their relevance to autoimmune diseases.
AIM 04Explore the effects of biological factors such as age and sex on immune responses to autoantigens.
AIM 05Develop better models for understanding and treating autoimmune hemolytic anemia.
Skills the Lab Values
mouse modelsflow cytometrytranscriptomic analysisimmunophenotypingT cell subset analysisbiological experimentationdata analysis in immunologydisease modelingexperimental design
Output against the department
Publications92bottom 31% of dept.716th of 1,033
this lab
most publishedleast published
Citations3.0kbottom 23% of dept.796th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.