Eastern Michigan University · ChemistryEvans Lab
Hedeel I. Guy Evans · Ypsilanti, Michigan
Research Focus
Dr. Hedeel I. Guy Evans' lab at Eastern Michigan University focuses on understanding the role of hyaluronan, a key component of the extracellular matrix, in cellular signaling and health. They investigate how hyaluronan interacts with proteins and receptors to influence cell viability and function, especially in relation to factors like nicotine and hypoxia. By uncovering these mechanisms, the lab aims to contribute to therapies that target diseases linked to hyaluronan dysregulation.
hyaluronanextracellular matrixcell signalingIGFBP-3apoptosis
Research Aims
3AIM 01Investigate how hyaluronan binding affects IGFBP-3 and amyloid beta interactions.
AIM 02Examine the role of nicotine in activating growth factor receptors to modulate hyaluronan levels.
AIM 03Explore how hypoxia-induced changes in hyaluronan influence cell survival and resistance to treatments.
Skills the Lab Values
cell cultureprotein-protein interaction assaysWestern blottingPCRimmunofluorescence microscopy
Output against the department
Publications11bottom 1% of dept.213th of 216
this lab
most publishedleast published
Citations104bottom 1% of dept.213th of 216
this lab
most citedleast cited
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